(R)-1,1,1-Trifluoropropan-2-ol
(R)-1,1,1-Trifluoropropan-2-ol is a chiral molecule with the molecular formula C₃H₅F₃O. Here’s a breakdown of its structure and properties:
Structure:
- Chirality: The molecule has a chiral center at the second carbon (C2), which is attached to four different groups: a hydroxyl group (-OH), a trifluoromethyl group (-CF₃), a hydrogen atom (-H), and a methyl group (-CH₃).
- Stereochemistry: The (R) designation indicates the absolute configuration of the chiral center, following the Cahn-Ingold-Prelog priority rules. The priority order of the groups is -CF₃ > -OH > -CH₃ > -H, and the arrangement of these groups determines the (R) configuration.
Key Features:
- Functional Groups: It contains a hydroxyl group (-OH), making it an alcohol, and a trifluoromethyl group (-CF₃), which is highly electronegative and can influence the molecule’s reactivity and physical properties.
- Polarity: The presence of the -OH and -CF₃ groups makes the molecule polar, affecting its solubility and boiling point.
Applications:
- Organic Synthesis: This compound can be used as a building block in organic synthesis, particularly in the preparation of fluorinated compounds.
- Pharmaceuticals: Fluorinated alcohols are often used in the synthesis of pharmaceuticals due to their unique electronic and steric properties.
Physical Properties:
- Boiling Point: Likely higher than non-fluorinated alcohols due to the presence of the -CF₃ group.
- Solubility: Soluble in organic solvents; solubility in water may be limited due to the hydrophobic -CF₃ group.
Safety:
- Handling: Standard precautions for handling alcohols and fluorinated compounds should be followed, including the use of appropriate personal protective equipment (PPE).
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